Deflazacort Tablet Uses, Alternatives, and Storage

A synthetic glucocorticoid member of the corticosteroid family is called deflazacort. It is used for its anti-inflammatory and immunosuppressive properties. Deflazacort tablet uses is mainly prescribed to treat various conditions that involve inflammation and immune system dysfunction.

It is often used to treat inflammatory and autoimmune diseases such as asthma, rheumatoid arthritis, lupus, dermatomyositis, and ulcerative colitis. It may also be used to treat allergic reactions and to prevent organ rejection after transplantation.

By inhibiting the immune system and lowering inflammation in the body, deflazacort works. It inhibits the production of certain chemicals that contribute to inflammation, helping to relieve the symptoms associated with these conditions.

It’s essential to be aware that although deflazacort can be an effective treatment for certain conditions, it can also have potential side effects. Common side effects include increased appetite, weight gain, fluid retention, mood changes, and changes in blood sugar levels. It is essential to follow the prescribed dosage and consult with a healthcare professional for advice and monitoring while using deflazacort.

How Does Deflazacort Work?

Deflazacort Tablet Uses

Deflazacort works by acting on different cells and processes in the body. As a synthetic glucocorticoid, it has similar effects to naturally occurring corticosteroids produced by the adrenal glands.

When deflazacort tablet uses is administered, it enters cells and binds to glucocorticoid receptors found in many tissues throughout the body. This receptor binding triggers a complex cascade of events that lead to its anti-inflammatory and immunosuppressive effects.

Here are some of the key mechanisms of action of deflazacort:

  • Anti-inflammatory effects: Deflazacort suppresses the production of pro-inflammatory molecules such as cytokines, chemokines, and prostaglandins. Reducing the release of these inflammatory mediators helps to reduce inflammation and relieve associated symptoms.
  • Immunosuppressive effects: Deflazacort has immunosuppressive properties, which means that it inhibits the activity of the immune system. It suppresses the function of immune cells such as lymphocytes and macrophages, thereby reducing immune responses and dampening autoimmune reactions.
  • Modulation of gene expression: Deflazacort affects gene expression by binding to glucocorticoid receptors in the nucleus of cells. This leads to the activation or repression of specific genes, resulting in changes in protein synthesis and cellular processes.
  • Stabilization of cell membranes: Deflazacort tablet uses helps to stabilize cell membranes, making them less permeable to inflammatory substances. This stabilizing effect reduces the influx of immune cells and inflammatory molecules into affected tissues.

Deflazacort Tablet Uses

Deflazacort is prescribed for a variety of conditions because of its anti-inflammatory and immunosuppressive properties. Here are some common uses for deflazacort:

  1. Inflammatory and autoimmune diseases: Conditions characterized by inflammation and abnormal immune responses are often treated with deflazacort. These may include
  • Rheumatoid arthritis: It may help reduce joint inflammation and relieve symptoms such as pain and stiffness.
  • Systemic lupus erythematosus (SLE): Deflazacort may be used to reduce inflammation in organs affected by lupus, such as the skin, joints, kidneys, and heart.
  • Dermatomyositis: It may help suppress the immune response and reduce muscle inflammation.
  • Inflammatory bowel disease: Deflazacort tablet uses to reduce inflammation in the gastrointestinal tract in the treatment of ulcerative colitis and Crohn’s disease.
  • Asthma: It may be used in the treatment of asthma to reduce inflammation in the airways and improve breathing.
  1. Allergic conditions: Deflazacort may be used to treat severe allergic reactions and conditions such as allergic rhinitis, allergic dermatitis, and contact dermatitis. It helps relieve symptoms such as itching, swelling, and inflammation associated with these allergies.
  1. Transplantation: Deflazacort is sometimes given to organ transplant recipients to prevent organ rejection. By inhibiting the immune system and lowering inflammation in the body, deflazacort works.
  2. Other uses: There may be other off-label uses for deflazacort that will be determined by your health care professional. These may include certain skin conditions, certain types of cancer, and certain eye conditions.

It’s important to note that the specific use of deflazacort tablets and the recommended dosage will depend on the individual’s medical condition, severity of symptoms, and other factors. A healthcare professional should be consulted to determine the appropriate use of deflazacort in each individual case.

Alternatives to Deflazacort

There are several alternatives to deflazacort that may be prescribed depending on the specific medical condition and individual patient factors. It’s important to note that the choice of alternative medication depends on the specific needs and responses of each patient. Here are some common alternatives to deflazacort

  • Prednisone: Prednisone is a corticosteroid medication similar to deflazacort. It is often used as an alternative for various inflammatory and autoimmune conditions. Prednisone has a similar mechanism of action and can be prescribed in comparable doses.
  • Methylprednisolone: Methylprednisolone is another corticosteroid that can be used as an alternative to deflazacort. It is often prescribed for conditions such as asthma, allergic reactions, and inflammatory conditions.
  • Dexamethasone: Dexamethasone is a powerful corticosteroid with anti-inflammatory and immunosuppressive effects. It is often used as an alternative to deflazacort for various conditions, including autoimmune diseases, certain cancers, and allergic reactions.
  • Prednisolone: Prednisolone is a corticosteroid that is often used as an alternative to deflazacort, especially in pediatric patients. It has similar anti-inflammatory and immunosuppressive properties and is prescribed for a range of inflammatory and autoimmune conditions.
  • Non-steroidal anti-inflammatory drugs (NSAIDs): For certain conditions, non-steroidal anti-inflammatory drugs such as ibuprofen or naproxen may be used as an alternative to corticosteroids. NSAIDs can help relieve pain and reduce inflammation but have a different mechanism of action than corticosteroids.
  • Disease-modifying anti-rheumatic drugs (DMARDs): For autoimmune diseases such as rheumatoid arthritis, DMARDs such as methotrexate, sulfasalazine or biologic agents such as TNF inhibitors may be prescribed as an alternative or in combination with corticosteroids.

 Deflazacort Tablets  Side Effects

Deflazacort Tablet Uses

Deflazacort, like other corticosteroids, may cause side effects. The severity and occurrence of these deflazacort tablets side effects may vary from person to person, depending on factors such as dosage, duration of use, and individual susceptibility. It’s important to note that not all people will experience these side effects, and some side effects are more common with long-term or high-dose use. Here are some of the possible side effects of deflazacort

  • Adrenal suppression: Prolonged use of deflazacort tablets may suppress the production of natural corticosteroids by the adrenal glands. Abrupt discontinuation or rapid reduction in dose may lead to adrenal insufficiency, characterized by symptoms such as fatigue, weakness, weight loss, and low blood pressure. It is therefore important to taper the dose gradually under medical supervision when stopping deflazacort.
  • Increased risk of infection: Deflazacort can weaken the immune system, making people more susceptible to infections. This includes an increased risk of bacterial, viral, and fungal infections. It is important to report any signs of infection, such as fever, sore throat, or persistent cough, to a healthcare professional immediately.
  • Gastrointestinal effects: Deflazacort may cause gastrointestinal deflazacort tablets side effects, including stomach irritation, stomach ulcers, and increased production of stomach acid. Taking deflazacort with food may help to minimize these effects.
  • Weight gain: Deflazacort may cause increased appetite and weight gain. It may cause a redistribution of fat, resulting in a “moon face” or increased fat deposits in the abdomen, face, or neck.
  • Mood changes: Corticosteroids can sometimes cause mood changes, ranging from irritability and mood swings to more serious psychological effects such as anxiety, depression, or even psychosis. It is important to monitor any changes in mood or mental well-being and discuss them with a healthcare professional.
  • Fluid retention: Deflazacort tablets may cause fluid retention, leading to swelling or edema in various parts of the body, such as the hands, feet, or face.
  • Bone loss: Prolonged use of corticosteroids such as deflazacort may increase the risk of osteoporosis (weakening of the bones) and bone fractures.
  • Other possible side effects: Other possible deflazacort tablets side effects include changes in blood sugar levels, increased blood pressure, thinning of the skin, easy bruising, cataracts, delayed growth in children, and muscle weakness.

It is important to note that this is not an exhaustive list of possible side effects. If you are prescribed deflazacort, it’s important to discuss possible deflazacort tablets side effects with your doctor or health care professional, report any symptoms of concern immediately, and have regular checks to minimize risks and manage side effects effectively.

Storage and Disposal of Deflazacort

When it comes to the storage and disposal of medicines such as deflazacort, it’s important to follow the correct guidelines to ensure their effectiveness, safety, and impact on the environment. Here are some common recommendations:


  • Follow instructions: Always refer to the specific storage instructions that are on the packaging of the medicine or as instructed by your health care professional.
  • Temperature: Store deflazacort tablets at room temperature, typically between 20°C and 25°C (68°F and 77°F).
  • Avoid light and moisture: Store in the original container, tightly closed, away from moisture and direct sunlight.
  • Accessibility and safety: Store deflazacort out of the reach of children and pets, preferably in a secure and elevated location.
  • Separate from other medicines: Store deflazacort separately from other medicines to avoid confusion and possible cross-contamination.


  • Comply with local regulations: Check local regulations and guidelines for the proper disposal of medicines. Some areas have specific guidelines or collection programs for disposing of medicines.
  • Do not flush or drain: Do not flush deflazacort tablets down the toilet or pour it down the drain as it may contaminate water supplies and harm the environment.
  • Take-back programs: If available, take advantage of drug take-back programs or collection events organized by pharmacies, healthcare facilities, or local authorities.
  • Dispose of household waste: If no special disposal programs are available, you can dispose of deflazacort in your household waste. Follow these steps:

a. Remove personal information: Remove or obliterate any personal information from the medication packaging.

b. Mix with undesirable substance: To prevent accidental or deliberate misuse, mix the medicine with an undesirable substance, such as coffee grounds or cat litter. This makes the deflazacort tablet side effects less attractive and reduces the risk of diversion.

c. Place in a sealed container: Put the mixture of deflazacort tablets and the undesirable substance in a sealable bag or container to prevent leakage.

  • Consult a pharmacist: If you are unsure about proper disposal methods, consult a pharmacist who can give you advice based on local regulations and recommendations.

Remember, it’s important to prioritize safety and environmental responsibility when storing and disposing of medicines. If you have any specific concerns or questions regarding the storage or disposal of deflazacort, it is best to consult your healthcare provider or pharmacist.

Overdose of Deflazacort

An overdose of deflazacort tablets can be serious and should be avoided. If you suspect an overdose, or if someone has accidentally taken more than the prescribed dose, it is important to seek immediate medical attention or contact your local poison control center. Here is some general information about deflazacort overdose

  • Symptoms: The signs and symptoms of an overdose may vary depending on the amount of medicine taken and other individual factors. Possible symptoms of an overdose may include an increased risk of deflazacort-related deflazacort tablets side effects such as fluid retention, electrolyte imbalance, high blood pressure, increased blood sugar levels, mood changes, and gastrointestinal upset.
  • Treatment: In the event of an overdose, treatment will focus on supportive measures to manage symptoms and minimize potential complications. It may include close monitoring of vital signs, management of fluid and electrolyte imbalances, symptomatic relief, and interventions based on the specific situation.
  • Avoid overdose: To avoid overdose, it is important to take exactly the prescribed dose and frequency of deflazacort. Follow your doctor’s instructions and never take more than the recommended dose without medical supervision.

It’s important to note that the above information is provided as a general guide. The appropriate actions to take and how to treat an overdose will depend on the specific circumstances and the judgment of the healthcare professional. In the event of an overdose, immediate medical attention is essential for appropriate assessment and treatment.

*Disclaimer: Please note that the information provided in this article is for educational purposes only and should not replace professional medical advice. Consult a healthcare professional for personalized guidance and recommendations regarding the deflazacort tablet uses and deflazacort tablets side effects.

Author Contribution: Reviewed by Dr Ram Reddy, MD – General Physician, and Rajeshwar Rao, Pharm D.

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