Epithelial Cells in Urine: Causes, Diagnosis, and Tips to Maintain Urinary Health

Your health and well-being depend on various factors, and one crucial aspect is your urinary system’s health. A routine urinalysis might sometimes reveal the presence of epithelial cells in urine, which can raise questions and concerns about your urinary health. In this comprehensive guide, we’ll dive into the world of epithelial cells in urine, exploring their causes, implications, and how to maintain optimal urinary health. 

Understanding Epithelial Cells in Urine

1. What are Epithelial Cells? 

Epithelial cells are a type of cell that lines the surfaces of organs and structures throughout your body. In the urinary system, they line the bladder, ureters, and urethra, acting as a protective barrier. While it’s normal to have a small number of epithelial cells in urine, an abnormal increase in their count may indicate an underlying issue. 

2. Normal Urine Epithelial Cell Count 

Before delving into the causes of an increased epithelial cell count in urine, it’s essential to understand what is considered normal. Generally, a healthy individual will have a few squamous epithelial cells (cells from the urethra) and transitional epithelial cells (cells from the bladder) in their urine sample. 

Epithelial Cells in Urine

Causes of Epithelial Cells in Urine

1. Urinary Tract Infections (UTIs): 

Urinary Tract Infections (UTIs) are among the most common causes of epithelial cells in urine that have increased in count. UTIs occur when bacteria, usually from the digestive tract, enter the urethra and travel up to the bladder and beyond. These bacteria can cause inflammation and irritation of the urinary tract’s epithelial lining, leading to the shedding of epithelial cells into the urine. 

Common symptoms of UTIs include frequent and painful urination, a strong urge to urinate, cloudy or bloody urine, and discomfort in the lower abdomen. If left untreated, UTIs can progress to more severe kidney infections, potentially leading to complications like pyelonephritis. 

2. Kidney Infections: 

Kidney infections, also known as pyelonephritis, are severe UTIs that affect one or both kidneys. When the infection spreads from the lower urinary tract to the kidneys, it can cause significant inflammation and damage to the kidney’s tubules and glomeruli. This damage is one of the causes of epithelial cells in urine that are increased in count.

The symptoms of kidney infections may include fever, chills, back pain, nausea, and vomiting, in addition to the typical UTI symptoms. Prompt treatment with antibiotics is essential to prevent complications and long-term kidney damage. 

3. Renal Tubular Acidosis (RTA): 

Renal Tubular Acidosis (RTA) is a group of kidney disorders that affect the kidney’s ability to maintain the body’s acid-base balance. In individuals with RTA, the renal tubules fail to adequately excrete acidic substances, leading to a buildup of acid in the blood and a decrease in urine acidity. This altered acidity in the urine can contribute to an increased presence of epithelial cells. 

The condition may be asymptomatic or present with non-specific symptoms such as weakness, fatigue, and frequent urination. Treatment aims to correct the acid-base imbalance and address the underlying cause of the disorder. 

4. Glomerulonephritis: 

Glomerulonephritis is a group of kidney diseases characterized by inflammation of the glomeruli, the filtering units of the kidneys. When the glomeruli become inflamed, they may lose their ability to effectively filter waste products and excess fluid from the blood, leading to proteinuria (presence of protein in urine) and hematuria (blood in urine). The damaged glomeruli can also release epithelial cells into the urine, contributing to an elevated epithelial cell count. 

Glomerulonephritis can be acute or chronic and may be caused by various factors, including infections, autoimmune diseases, and certain medications. Management and treatment depend on the specific type and severity of the condition. 

5. Kidney Stones: 

Kidney stones are hard mineral and salt deposits that form within the kidneys. When these stones pass through the urinary tract, they can cause irritation and damage to the epithelial lining, leading to an increased number of epithelial cells in the urine. 

The symptoms of kidney stones can be excruciating and may include severe pain in the back, side, abdomen, or groin, as well as hematuria and frequent urination. Treatment options vary depending on the size and location of the stones and may involve medication, lithotripsy (sound wave treatment), or surgical removal. 

6. Cystitis: 

Cystitis is the inflammation of the bladder, often caused by bacterial infections. When the bladder becomes inflamed, it will lead to being one of the causes of epithelial cells in urine that is, an increased cell count.

Common symptoms of cystitis include a strong, persistent urge to urinate, burning sensation during urination, cloudy or bloody urine, and discomfort in the lower abdomen. Cystitis is more common in women due to the shorter length of their urethra, making it easier for bacteria to reach the bladder.  

Epithelial Cells in Urine

Diagnosing Epithelial Cells in Urine

Diagnosing the presence of epithelial cells in urine is a crucial step in assessing urinary health and identifying potential underlying issues. A thorough diagnostic approach involves various tests and examinations, each providing valuable insights to guide appropriate medical intervention. Let’s delve into the different methods used for diagnosing epithelial cells in urine: 


Urinalysis is a standard diagnostic procedure that involves analyzing a urine sample to detect abnormalities in its physical, chemical, and microscopic properties. It is a non-invasive and cost-effective test that can be performed in a medical laboratory. During a routine urinalysis, the following aspects are evaluated: 

Physical Properties: In this stage, the color, clarity, and odor of the urine are assessed. Normal urine is typically pale yellow and clear. Any unusual color or cloudiness may warrant further investigation. 

Chemical Properties: The chemical composition of urine is examined using test strips that change color in response to specific substances present in the urine. These strips can detect indicators of urinary tract infections, kidney problems, and other abnormalities. 

2. Microscopic Examination: 

Once the initial urinalysis is completed, a microscopic examination of the urine sample is conducted. This involves examining a small amount of urine under a microscope to identify and quantify different elements present, including epithelial cells. 

Squamous Epithelial Cells: These cells are derived from the lining of the urethra and can be found in small quantities in the urine of both men and women. In females, they may also come from the vaginal canal. A higher than normal count of squamous epithelial cells may indicate contamination of the urine sample. 

Transitional Epithelial Cells: These cells originate from the lining of the bladder and can be found in the urine in small quantities. An elevated number of transitional epithelial cells may indicate inflammation or infection in the urinary bladder. 

Renal Epithelial Cells: These cells come from the renal tubules of the kidneys and are not commonly found in normal urine. An increased presence of renal epithelial cells could indicate kidney damage or disease. 

3. Additional Tests: 

In some cases, when the microscopic examination reveals a significant number of epithelial cells or when there are other concerning findings, additional tests may be necessary to pinpoint the exact cause of the abnormalities. Some of these tests may include: 

Urine Culture: A urine culture is conducted to identify the specific bacteria causing a urinary tract infection. It helps determine the most appropriate antibiotic treatment. 

Cytology: Urine cytology is a specialized test where a pathologist examines urine samples under a microscope to detect abnormal or cancerous cells. This test is especially important when there are suspicious findings during the microscopic examination. 

Imaging Studies: In cases where urinary tract issues or kidney problems are suspected, imaging studies such as ultrasound, CT scan, or MRI may be conducted to visualize the structures of the urinary system and identify any abnormalities. 

Biopsy: In rare instances where more serious conditions, such as kidney disease or bladder cancer, are suspected, a biopsy may be performed. A small tissue sample is taken from the affected area and examined under a microscope to provide a definitive diagnosis. 

It is essential to note that a single presence of epithelial cells in urine does not necessarily indicate a health problem. Factors like contamination during sample collection or hormonal changes can affect the results. However, persistent and significant elevation in epithelial cell count should be addressed by a healthcare professional to rule out any underlying medical conditions.  

The Significance of Epithelial Cells in Urine

The presence of epithelial cells in urine can be indicative of various urinary tract issues. While it’s essential to identify the underlying cause, it’s equally crucial to understand that the presence of a few epithelial cells might not always be a cause for alarm. 

Causes of epithelial cells in urine.

Tips to Maintain Urinary Health

A well-functioning urinary system is vital for maintaining overall health and well-being. To ensure your urinary tract remains in top shape and to reduce the risk of potential complications, consider implementing the following tips into your lifestyle: 

1. Stay Hydrated: 

One of the simplest yet most effective ways to promote urinary health is to stay adequately hydrated. Drinking plenty of water throughout the day helps to flush out toxins, bacteria, and other harmful substances from the urinary tract. It also dilutes urine, reducing the risk of crystallization and stone formation. 

Aim to drink at least 8-10 cups (64-80 ounces) of water daily. If you engage in physical activities or live in a hot climate, you may need to increase your water intake to compensate for fluid loss through sweat. 

2. Practice Good Hygiene: 

Maintaining proper hygiene is crucial in preventing urinary tract infections (UTIs) and other urinary-related issues. Always remember to: 

  • Wash your genital area with mild soap and water regularly. 
  • After using the restroom, wipe from front to back to prevent the spread of bacteria from the anal area to the urethra. 
  • For women, avoid using scented products or douches in the genital area, as they can disrupt the natural balance of bacteria. 

3. Urinate Regularly: 

Holding in urine for extended periods can lead to various problems, including UTIs and urinary retention. When you feel the urge to urinate, make it a priority to find a restroom and empty your bladder promptly. Frequent urination helps prevent the buildup of bacteria in the urinary tract and reduces the risk of infections. 

4. Maintain a Balanced Diet: 

What you eat can significantly impact your urinary health. A well-balanced diet provides essential nutrients and supports the proper functioning of your kidneys and urinary system. Consider the following dietary tips: 

  • Incorporate plenty of fruits and vegetables, which are rich in vitamins, minerals, and antioxidants. These nutrients help protect your urinary tract from damage caused by free radicals. 
  • Include foods that are high in fiber to maintain healthy bowel movements and prevent constipation. Constipation can put pressure on the bladder and increase the risk of urinary retention. 
  • Reduce your intake of salt and processed foods, as excessive sodium can lead to water retention and strain the kidneys. 

5. Avoid Irritants: 

Certain substances can irritate the urinary tract and exacerbate existing conditions. To maintain a healthy urinary system, consider reducing or avoiding the following irritants: 

  • Caffeine: Found in coffee, tea, energy drinks, and some sodas, caffeine can act as a diuretic, leading to more frequent urination. It may also irritate the bladder in some individuals. 
  • Alcohol: Drinking alcohol can dehydrate the body, and excessive consumption can lead to increased urination and irritate the urinary tract. 
  • Spicy and Acidic Foods: Some individuals may find that consuming spicy or acidic foods can trigger bladder irritation. Pay attention to your body’s response to these foods and adjust your diet accordingly. 

6. Practice Safe Sexual Activities: 

Sexual activities, especially without proper precautions, can increase the risk of UTIs. To reduce this risk: 

  • Urinate before and after sexual intercourse to flush out any bacteria that may have entered the urethra during the activity. 
  • Use condoms or other barrier methods to protect against sexually transmitted infections, which can lead to urinary health issues if left untreated. 

7. Exercise Regularly: 

Regular physical activity benefits the entire body, including the urinary system. Exercise promotes circulation, which is essential for optimal kidney function. It can also help maintain a healthy weight, reducing the risk of conditions like diabetes and obesity that can negatively affect urinary health. 

8. Quit Smoking: 

Smoking is harmful to the entire body, including the urinary system. Smoking can damage blood vessels, decrease blood flow to the kidneys, and increase the risk of kidney problems. Quitting smoking can significantly improve your overall health, including the health of your urinary system. 

9. Manage Stress: 

Chronic stress can have a negative impact on the body and may contribute to urinary issues. Stress can lead to hormonal imbalances that affect kidney function and weaken the immune system, making it more susceptible to infections. Practice stress-reducing techniques such as meditation, deep breathing exercises, yoga, or spending time in nature. 

10. Regular Check-ups: 

Even if you feel healthy, it’s crucial to schedule regular check-ups with your healthcare provider. Routine check-ups can detect potential issues early on and allow for timely intervention and treatment if needed. Your healthcare provider can also provide personalized advice on maintaining optimal urinary health based on your individual needs and medical history.  


Your health is your most valuable asset, and maintaining a healthy urinary system is crucial to your overall well-being. Causes of Epithelial cells in urine with some other information included, can provide essential insights into your urinary health, and any significant deviations from normal levels warrant attention and medical evaluation. By understanding the causes, implications, and implementing preventive measures, you can take control of your urinary health and lead a healthy, fulfilling life. Remember, always consult a healthcare professional for personalized advice and guidance. 

*Disclaimer: The information provided in this article is for educational purposes only and should not replace professional medical advice. It is important to consult a healthcare professional for accurate diagnosis and treatment. 

Author Contribution: Reviewed by Dr. Ram Reddy, MD – General Physician.

Add a Comment

Your email address will not be published. Required fields are marked *